Have you run b18, or b19 before? This sounds like a problem that appeared before.
If the database was saved before by b18, or b19 an integrity seal was added to it to check for corruption or tampering. If you subsequently opened and modified it with an earlier version of Panorama, the integrity seal wouldn’t have been updated to match the change.
You can turn that feature off in your preferences in b18 or later, and it will open the file.
