I have encountered exactly the same issue. This occurred after reinstalling Panorama 6 on a new drive and solving the permissions issues. I was just about to post to the forum when I found this thread. The solution described here also worked for me. When I used Save As to make a new copy of the file, it would open in response to the Openfile command. I will be so glad when the PanX server is functional and I can abandon Pan6, since I spent at least three or four hours dealing with the installation and then Openfile issues.